XN-31
XN-31 – La lutte contre le paludisme commence par un diagnostic rapide et sûr
- Quantification de la concentration du parasite de la malaria (nombre absolu et % parasitémie)
- Au moyen de la cytométrie en flux par fluorescence (limite de détection: 20 parasites/µl)
- Quantification des gamétocytes (paramètre de recherche)
- Y compris paramètres de la petite formule sanguine
- Mesure par pression d’un bouton, sans préparation des échantillons et indépendante du savoir-faire de l’utilisateur (60 échantillons/h)
Le paludisme reste l'un des plus importants problèmes de santé publique dans le monde. Selon le rapport OMS 2018, plus de 3,2 milliards de personnes dans 91 pays courent un risque d'infection. Un diagnostic précoce et précis du paludisme est essentiel dans la lutte contre le paludisme. Un traitement rapide et spécifique permet de prévenir les complications et de réduire la mortalité. L'analyseur XN-31 automatisé permet de détecter et de compter les globules rouges infectés par le parasite de la malaria en une minute (MI-RBC) avec une excellente sensibilité et spécificité (Pillay et al*).
Clinical insight
- Be confident fighting malaria: accurate enumeration and direct detection of the parasite facilitates reliable diagnosis.
- Consistent standard LoQ (20 parasites/μL) independent of the operator’s skill.
- All Plasmodia species are detectable.
- The high precision supports reliable monitoring of treatment efficacy.
- The concurrent CBC measurement provides clinicians with important information for clinical correlation.
- Anaemia is a major contributor to mortality in malaria.
- The degree of thrombocytopenia provides an indication of the severity of malaria.
- The WBC count could be helpful to give an indication of other concurrent infections.
Productivity
- The XN-31 incorporates Sysmex’s proven technologieswell established for the haematology analysers.
- By utilising this automated solution your lab canshorten the TAT while ensuring a highly sensitive detectionof malarial parasites.
- Operating the analyser is easy and does not require amalaria expert.
- The integrated sampler allows high sample throughputand walk-away time.
- The MI-RBC parameters are stable and unaffected by room temperature, which enables the processing of specimens collected and transported appropriately from remote locations.
- Maintenance requirements are minimal whilst being very simple and easy to execute.
- Quality control material for malaria detection available.
| XN-31 configuration | stand-alone |
| Measurement principles | MI-RBC and WBC: fluorescence flow cytometry RBC and PLT: impedance method with hydrodynamic focussing HGB: cyanide-free SLS haemoglobin |
| Aspiration volume: (venous blood sample) | [LM] mode*: 60 μL [PD] mode: 70 μL (out of 20 μL blood + 120 μL diluent) Throughput [LM] mode*: 55 samples/ hour [PD] mode: 60 samples/ hour |
| Diagnostic parameters | CBC + M channel: WBC, RBC, HGB, HCT, MCV, MCH, MCHC, PLT, RDW-SD, RDW-CV, MPV, PDW, P-LCR, PCT, MI-RBC#, MI-RBC% |
| Research information | information related to the life stage of the malarial parasite |
| Flagging information | information on the malarial parasite species (Plasmodium falciparum or others) |
| Limit of quantification (LoQ) | [LM] mode*: 0.020 x 103/μL [PD] mode: 0.040 x 103/μL |
| Quality control: | Xbar or Levey–Jennings XN Check material Patient sample-based quality control (XbarM) |
| Dimensions (w x h x d) | Main unit including the sampler SA-10: 645 mm x 855 mm x 755 mm Pneumatic unit: 280 mm x 400 mm x 355 mm |
| Weights | Main unit including the sampler SA-10: approx. 78 kg Pneumatic unit: approx. 17 kg |
| Interface | LIS (LAN port) |
* LM mode: default sample measurement mode, PD mode: pre-diluted mode for samples with inadequate volume
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+41 24 423 93 93
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Quiz: https://sysmex-academy.com/learn/malaria-test-your-knowledge-0
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