Literatur

This white paper intents to give an overview of the most common types of anaemia with a focus on how haematological parameters such as RET-He and other advanced RBC parameters could help to distinguish different causes of anaemia. The white paper also summarises current guidelines and publications on advanced RBC parameters.

Haemostasis is a complex process that helps to keep the blood in a fluid state and prevent blood loss at the site of injury. While the intact endothelium of blood vessels has an anti-thrombogenic function that prevents blood coagulation, in the case of vessel wall damage, the exposed sub-endothelial components initiate the formation of a clot that will stop blood loss.

Sysmex Educational Enhancement and Development June 2012

Akute myeloische Leukämie (AML) mit abnormen Eosinophilen

B-zelluläre akute lymphatische Leukämie (B-ALL)

Ein 12-jähriger Junge wurde mit blutiger Diarrhö, Bauchkrämpfen, Fieber, Nausea und Hämatomen in die Notaufnahme eingeliefert. Die Blutuntersuchung zeigte eine Thrombozytopenie (23.000/μL), eine Erhöhung der Fraktion der unreifen Thrombozyten, eine Retikulozytose sowie das Vorliegen von Fragmentozyten und unreifen Granulozyten.

Systemischer Lupus erythematodes (SLE) unter Immunsuppressionstherapie

Automated haematology analysers with the ability to differentiate white blood cells are widely available in routine haematology laboratories and broadly classified as either 3-part or 5-part differential analysers. This SEED article explains the differences in the measurement technology and the benefits that 5-part differential analysers offer such as a more comprehensive flagging system for the detection of abnormal cells or the availability of extended information from additional measurement channels such as the WPC channel.

The detection of blast cells in the peripheral blood is considered extremely important, and great responsibility is placed on the investigating laboratory. As well as information on the physiology, this SEED article describes the possible causes of the release of blast cells into the blood, the characteristics by which they can be identified and how further diagnosis is carried out.